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Neuropathy, nephropathy, foot ulcers, and sarcopenia are symptoms of persistent hyperglycemia, lipotoxicity, excess branched-chain amino acids, and deficiencies in magnesium, zinc, and vitamin D that impair insulin signaling, mitochondrial integrity, and tissue repair

Historical Clinical Trials (1980s) The most direct evidence for DSIP as a sleep therapeutic comes from a series of clinical trials conducted in the late 1970s and early 1980s

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Collectively, these findings have significantly advanced our understanding of the gut-brain axis